Changes in Red Blood Cell Behavior during Cerebral Blood Flow Increase in the Rat Somatosensory Cortex : A Study of Laser-Doppler Flowmetry

この論文にアクセスする

この論文をさがす

著者

抄録

The purpose of this study was to investigate red blood cell (RBC) behavior during an increase in local cerebral blood flow (LCBF). We measured changes in RBC behavior by using laser-Doppler flowmetry (LDF) in &agr;-chloralose-anesthetized rats. An increase in LCBF was carried out by approximately 2.5 and 4.0% CO2 inhalation and activation of the somatosensory cortex. The activation of the cortex was induced by electrical stimulation of the hind paw with 1.5-mA pulses (0.1 ms) applied at frequencies of 0.2, 1, 5, and 10 Hz for a 5 s duration. The increases in LCBF and RBC velocity during both CO2 inhalations were larger than that in RBC concentration (p < 0.05). LCBF and RBC velocity during 4.0% CO2 inhalation were larger than those during 2.5% CO2 inhalation (p < 0.05), though there was no significant difference in RBC concentration between the two conditions, suggesting a limitation of capillary volume. During somatosensory stimulation, the evoked LCBF increased with increasing stimulus frequency up to 5 Hz and decreased at 10 Hz. The responses of RBC concentration at 0.2 and 10 Hz were greater than those of RBC velocity (p < 0.05), but no significant differences in response magnitude were found at 1 and 5 Hz between RBC concentration and RBC velocity. These results suggest that the increase in LCBF during neuronal activity is different from that of controlling the LCBF as induced by CO2, and that the regulation of RBC concentration and RBC velocity is controlled by independent mechanisms.

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 51(6), 703-708, 2001-12-01

    日本生理学会

参考文献:  26件中 1-26件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008295392
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    6069562
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  IR 
ページトップへ