Impact of Diffusional Oxygen Transport Oxidative Metabolism in the Heart

• TAKAHASHI Eiji

  Department of Physiology, Yamagata University School of Medicine

• DOI Katsuhiko

  Department of Physiology, Yamagata University School of Medicine

書誌事項

タイトル別名

• Impact of Diffusional Oxygen Transport on Oxidative Metabolism in the Heart.
• Impact of Diffusional Oxygen Transport

抄録

The resistance for the oxygen molecule to diffuse from the capillary blood to the cell surface produces remarkably large gradients of oxygen partial pressure (PO₂) in the extracellular space. In addition, the intracellular radial gradients of PO₂ may not be ignored particularly when the cellular oxygen consumption is increased. These PO₂ gradients together result in a quite low intracellular PO₂ in the cardiomyocyte in vivo. Thus, the cellular oxidative metabolism may be limited by diffusional transport of oxygen from the capillary blood to mitochondria. In this review, quantitative aspects and physiological relevances of the PO₂ gradient in the myocardium are discussed.

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 48 (4), 243-252, 1998

  一般社団法人　日本生理学会

キーワード

• intracellular oxygen
• diffusion
• heart
• PO<SUB>2</SUB> gradient
• oxidative phosphorylation

詳細情報

• CRID: 1390001205043027584
• NII論文ID: 130004435673
• NII論文ID: 10008304843
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.48.243
• COI: 1:STN:280:DyaK1cvjsVKhug%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 4569909
• PubMed: 9757140
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4569909
• Web Site: https://search.jamas.or.jp/link/ui/1999055211
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可