ATP-Sensitive Potassium Channels : Structures, Functions, and Pathophysiology

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ATP-sensitive potassium channels (K<SUB>ATP</SUB> channels) play important roles in various tissues by coupling cell metabolic status to electrical activity. Recently, molecular biological and electrophysiological techniques have revealed the molecular basis of the K<SUB>ATP</SUB> channels to be a complex of the Kir6.0 subunit, a member of the inwardly rectifying K<SUP>+</SUP> channel subfamily Kir6.0, and the sulfonylurea receptor (SUR) subunit, a member of ATP-binding cassette (ABC) superfamily; the functional diversity of the various K<SUB>ATP</SUB> channels is being determined by a combination of the Kir6.0 subunit (Kir6.1 or Kir6.2) and the SUR subunit (SUR1 or SUR2) comprising it. Recent studies of the K<SUB>ATP</SUB> channels have suggested mechanisms of K<SUB>ATP</SUB> channel regulation and pathophysiology and also a new model in which ABC proteins regulate the functional expression of ion channels.

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 48(6), 397-412, 1998-12-01

    日本生理学会

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各種コード

  • NII論文ID(NAID)
    10008305518
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0021521X
  • NDL 記事登録ID
    4652803
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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