Cytoplasmic Free Concentrations of Ca2+ and Mg2+ in Skeletal Muscle Fibers at Rest and during Contraction.
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- KONISHI Masato
- Department of Physiology, The Jikei University School of Medicine
書誌事項
- タイトル別名
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- Cytoplasmic Free Concentrations of Ca2プラス and Mg2プラス in Skeletal Muscle Fibers at Rest and during Contraction
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This review summarizes estimates for cytoplasmic-free concentrations of Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) at rest and during contraction of skeletal muscles, from which substantial quantitative information about them has been accumulated. Although the estimates of resting [Ca2+]i in the literature widely differ, which is because of the variety of difficulties related to different methodologies used, recent studies suggest that estimates of resting [Ca2+]i of approximately 0.05-0.1 μM are likely to be correct. Following action potential propagation, the Ca2+ release from the sarcoplasmic reticulum causes a transient rise of [Ca2+]i (Ca2+ transient). The large peak amplitude and brief time course of the Ca2+ transients have been established only recently by studies with low-affinity Ca2+ indicators developed in the past decade. These technical improvements in [Ca2+]i measurements have made it possible to study relationships between [Ca2+]i and force in intact muscle fibers. in the second part of this review, various estimates of [Mg2+]i in the resting muscle are discussed. Relatively recent estimates of the [Mg2+]i level appear to be about 1.0 mM. Using the current knowledge of concentrations and reaction properties of intracellular Ca2+ -Mg2+ binding sites, we constructed a model for dynamic Mg2+ movement following Ca2+ transients. The model predicts that with a train of action potentials, the sustained rise of [Ca2+]i produces an elevation of [Mg2+]i of about 220 μM.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 48 (6), 421-438, 1998
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205042931712
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- NII論文ID
- 10008305701
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DyaK1MXhsFCnsLs%3D
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- ISSN
- 18811396
- 0021521X
- http://id.crossref.org/issn/0021521X
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- NDL書誌ID
- 4652846
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- PubMed
- 10021496
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可