CBF Change Evoked by Somatosensory Activation Measured by Laser-Doppler Flowmetry : Independent Evaluation of RBC Velocity and RBC Concentration

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著者

    • Seki Chie [他] SEKI Chie
    • Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute of Brain and Blood Vessels
    • KASHIKURA Kenichi
    • Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute of Brain and Blood Vessels
    • KANNO Iwao
    • Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels

抄録

The purpose of this study was to examine the timing and magnitude of neuronal activation. We measured the changes in local CBF(LCBF), red blood cell(RBC) velocity and RBC concentration by laser-Doppler flowmetry (LDF) as well as field potential recordings during activation of the somatosensory cortex of the rat in response to alactrical stimulation of the hind paw. Electrical stimuli, 0.1 ms pulses of 1-1.5 mA for 5 s, were applied at 0.2,0.5,5,10 and 50 Hz under α-chloralose anesthesia. LCBF showed the maximum increase at 5 Hz, and rose approximately 0.5 s after the onset of stimulation regardless of the frequency. The maximum freaquency of the filed potentials was also obtained at 5 Hz. During activation of the somatosensory cortex, the onset of rise in RBC concentration did not precede that of RBC velocity, and the peak RBC concentrasion was noted earlier than that both LCBF and RBC velocity, suggesting that both arteriolar diameter and active changes in the capillary contributed to the LCBF response.

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 49(3), 289-296, 1999-06

    日本生理学会

参考文献:  39件中 1-39件 を表示

被引用文献:  12件中 1-12件 を表示

各種コード

  • NII論文ID(NAID)
    10008307230
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    4867864
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  IR  J-STAGE 
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