Central Control Mechanisms of Circulation in the Medulla Oblongata by Nitric Oxide

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著者

    • Maeda Masanobu MAEDA Masanobu
    • Department of Systems Physiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
    • Inoue Masaiwa INOUE Masaiwa
    • Department of Systems Physiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
    • Takao Seiji [他] TAKAO Seiji
    • Department of Systems Physiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

抄録

Nitric oxide (NO) is involved in numerous physiological functions. Besides its role as an endothelium-dependent relaxing factor (EDRF), NO inhibits platelet aggregation, contributes to cytotoxicity against bacteria, is active in synaptic transmission within the brain, etc. NO synthase (NOS) is distributed in brain regions related to the regulation of cardiovascular functions. NO has been inferred not only to act directly on vascular vessels, but also to regulate circulation within the brain. In this review paper, we mainly consider the functions of NO in the cardiovascular center of the medulla oblongata. That is, we describe the anatomical distribution of NOS in the brain, effects of intravenous and intracerebroventricular administration of NOS inhibitors on the circulation, effects of microinjection of NO donors and NOS inhibitors into the nucleus tractus solitarius (NTS) and ventrolateral medulla (VLM), the results of electrophysiological studies on these areas, and finally, the data obtained by new molecular biological techniques.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 49(6), 467-478, 1999-12-01

    PHYSIOLOGICAL SOCIETY OF JAPAN

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被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008308052
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0021521X
  • NDL 記事登録ID
    4979582
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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