Haloperidol Prolongs Diastolic Phase of Ca^<2+> Transient in Cardiac Myocytes

この論文にアクセスする

この論文をさがす

著者

抄録

Haloperidol (HPL), a widely used antipsychotic drug, is known to induce serious ventricular arrhythmias. However, the mechanism underlying their induction is not clear. We therefore examined the effects of HPL on the intracellular Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) transient and on cell motion in cultured cardiac myocytes, as well as the pathways involving the HPL-induced abnormality of Ca<sup>2+</sup> homeostasis. HPL prolonged the diastolic phase of the Ca<sup>2+</sup> transient, with a mid-diastolic re-elevation of [Ca<sup>2+</sup>]<sub>i</sub>. The re-elevation of [Ca<sup>2+</sup>]<sub>i</sub> was shown to be provoked by Ca<sup>2+</sup> release from sarcoplasmic reticulum (SR), which can trigger delayed afterdepolarization, the major arrhythmogenic factor. The re-elevation of [Ca<sup>2+</sup>]<sub>i</sub> coincided with cell re-contraction during diastole. The induction of this abnormality by HPL appears to be independent of the mechanisms of the antipsychotic action.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 49(6), 479-484, 1999-12-01

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  20件中 1-20件 を表示

各種コード

  • NII論文ID(NAID)
    10008308164
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0021521X
  • NDL 記事登録ID
    4979586
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ