Inhibition of Ca^<2+> Entry Caused by Depolarization in Acetylcholine-Stimulated Antral Mucous Cells of Guinea Pig : G Protein Regulation of Ca^<2+> Permeable Channels

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The effects of depolarizing conditions resulting from increasing extracellular K<sup>+</sup> concentration or nystatin treatment on intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) were studied in guinea pig antral mucous cells following acetylcholine (ACh) stimulation. ACh stimulation evoked a biphasic increase in [Ca<sup>2+</sup>]<sub>i</sub>, that is, an initial transient increase followed by a plateau. Depolarizing conditions reduced the [Ca<sup>2+</sup>]<sub>i</sub> in the plateau phase during ACh stimulation. However, pertussis toxin (PTX, a G protein inhibitor) treatment caused [Ca<sup>2+</sup>]<sub>i</sub> in the ACh-evoked plateau phase to increase under depolarizing conditions, while it had no effect on [Ca<sup>2+</sup>]<sub>i</sub> under hyperpolarized conditions. Based on these observations, Ca<sup>2+</sup> permeable channels are regulated by a G protein which is activated by depolarized conditions and inhibited by hyperpolarized conditions and PTX; activation of the G protein (depolarization) causes Ca<sup>2+</sup> permeable channels to inhibit, and in turn, inhibition of the G protein (hyperpolarization) causes them to activate.<br>

収録刊行物

  • The Japanese journal of physiology

    The Japanese journal of physiology 49(6), 545-550, 1999-12-01

    PHYSIOLOGICAL SOCIETY OF JAPAN

参考文献:  14件中 1-14件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008308372
  • NII書誌ID(NCID)
    AA00691224
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    0021521X
  • NDL 記事登録ID
    4979622
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z53-D40
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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