A case report of lymphomatoid granulomatosis (LYG) with spontaneous attenuation.

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  • Homma Rie
    Department of Medicine, Teikyo University School of Medicine
  • Nakano Junichi
    Department of Medicine, Teikyo University School of Medicine
  • Yamashita Naomi
    Department of Medicine, Teikyo University School of Medicine
  • Oka Teruaki
    Department of Pathology, Kanto Chuo Hospital
  • Ohta Ken
    Department of Medicine, Teikyo University School of Medicine

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  • 胸腔鏡下肺生検により診断されたまれな臨床経過を呈したｌｙｍｐｈｏｍａｔｏｉｄ　ｇａｎｕｌｏｍａｔｏｓｉｓ（ＬＹＧ）の１例

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Abstract

70 years old woman was admitted to our hospital for the evaluation of multiple nodular shadows on chest X-ray. She had no clinical symptoms despite of mild increase of LDH and decrease of PaO2 on laboratory examination. Video associated thoracic surgery was performed to obtain lung tissue for the pathological diagnosis. Pathological findings suggested a diagnosis of lymphomatoid granulomatosis (LYG) for her lung nodules, which was confirmed by rearrangement of IgJH with nested PCR of lung tissue. Nodular shadows in her lung had a trend to regress in accordance with decreases of makers for lymphoma such as sIL-2 R, thymidine kinase, and beta 2-microglobulin without any medication. This is a rare case report of LYG with spontaneous attenuation in the clinical couerse.

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