Niceritrol decreases serum phosphate levels in chronic hemodialysis patients.
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- SHIMODA Kenji
- Seisyokai Hijiribashi Clinic
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- AKIBA Takashi
- Second Department of Internal Medicine , Tokyo Medical and Dental University
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- MATSUSHIMA Teruhiko
- Internal Medicine , Tsukuba Memorial Hospital, Ibaragi
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- RAI Tatemitsu
- Second Department of Internal Medicine , Tokyo Medical and Dental University
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- ABE Kaoru
- Seisyokai Kikukawabashi Clinic
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- HOSHINO Masanobu
- Seisyokai Kikukawabashi Clinic
Bibliographic Information
- Other Title
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- Niceritrolは慢性維持血液透析患者において血清無機リン濃度を低下させる
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Abstract
Since phosphorus retention in hemodialysis (HD) patients is known to be an important factor in the development of secondary hyperparathyroidism and renal osteodystrophy, phosphate binders have been needed for the control of serum phosphate levels (P). However, the calcium-containing phosphate binders that have been used widely can cause a rise in serum calcium levels and cause secondary hypoparathyroidism. We have recently experienced decreases in P after the administration of niceritrol (NT), a prodrug of nicotinic acid, for the treatment of low HDL-cholesteremia (HDL-C) in HD patients. The aim of the present study was to assess the mechanism of the P-lowering effect of NT in comparison with nicomol (NC), another prodrug of nicotinic acid. NT (750 mg/day) or NC (600 mg/day) was given orally to 10 or 14HD patients respectively. Blood samples were collected before the first dialysis of each week for the determination of serum urea nitrogen (UN), Cr, Ca, P, total cholesterol (TC), triglyceride (TG) and HDL-C. Serum nicotinic acid concentration (NAC) by gas chromatograph mass-spectrometry method was determined before, 4 weeks and 8 weeks after the administration of these drugs. After NT administration, P was decreased from 6.2±0.4 mg/dl to 5.1 ±0.4 mg/dl (1st week, p 0.001, Mean ±SE) and 4.5±0.3 mg/dl (2nd weeks, p<0.001) with no change in UN, Cr or Ca levels ; these significant decreases in P lasted for 8 weeks. NAC increased significantly after NT administration from 25.5±1.3 ng/ml to 549.8± 102.2 ng/ml (4 weeks, p < 0.01) and 431.7±51.4 ng/ml (8 weeks, p < 0.01). HDL-C also increased (33.6±4.0 mg/dl vs 42.7±4.6 mg/dl, p<0.05), but TC and TG did not change. In contrast, no significant changes were observed in P, NAC and HDL-C after NC administration. These discrepancies could be ascribed to the differencies in serum NAC levels. These data suggest that NT could be useful for the control of P in HD patients. However further studies are needed to confirm the mechanism of the P-lowering effect of NT.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 40 (1), 1-7, 1998
Japanese Society of Nephrology
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Details 詳細情報について
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- CRID
- 1390001204859354752
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- NII Article ID
- 130004170428
- 10008361959
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- NII Book ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- PubMed
- 9513376
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed