Effects of folic acid supplementation on hyperhomocysteinemia in CAPD patients: Effects on unsaturated fatty acids.

• HIROSE Satoru

  Saitama Medical Center, Fourth Department of Internal Medicine

• KIM Songsu

  Saitama Medical Center, Fourth Department of Internal Medicine

• MATSUDA Akihiko

  Saitama Medical Center, Fourth Department of Internal Medicine

• ITAKURA Yukihiro

  Saitama Medical Center, Fourth Department of Internal Medicine

• MATSUMURA Osamu

  Saitama Medical Center, Fourth Department of Internal Medicine

• TAMURA Hirokazu

  Saitama Medical Center, Fourth Department of Internal Medicine

• NAGASAWA Ryuji

  Saitama Medical Center, Fourth Department of Internal Medicine

• MITARAI Tetsuya

  Saitama Medical Center, Fourth Department of Internal Medicine

• ISODA Kazuo

  Saitama Medical Center, Fourth Department of Internal Medicine

Bibliographic Information

Other Title

• ＣＡＰＤ患者の高ｈｏｍｏｃｙｓｔｅｉｎｅ血症に対する葉酸投与の検討　　不飽和脂肪酸への効果

Abstract

Hyperhomocysteinemia has been recognized as one of the risk factors for atherosclerosis and premature vascular disease. Patients on dialysis and end-stage renal disease also manifest high plasma concentrations of homocysteine. We performed this study to evaluate the effects of folic acid supplementa tion on hyperhomocysteinemia in CAPD patients. Twenty-three CAPD patients (8 males, 15 females, 49.1±14.2-years-old) dialyzed for 22.7±19.2 months participated in the study. Daily 5-mg doses of folic acid supplementation for 4 weeks significantly reduced plasma concentrations of total homocysteine (p < 0.01) and serine (p < 0.001) . This observation suggests that the reduction of plasma concentrations of total homocysteine results from activation of homocysteine remethylation to methionine. On the other hand, folic acid supplementation also revealed significant correlations between changes in serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid and changes in plasma concentrations of total homocysteine (r = -0.517, p<0.05, r = -0.451, p<0.05, respectively) . In addition, serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid in 11 CAPD patients with hyperhomocysteinemia (≥ 35 micromol/litter) were significantly lower than those of 12 CAPD patients with normohomocys teinemia ( < 35 micromol/litter) (p < 0.05, p < 0.05, respectively). Serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid in CAPD patients with hyperhomocysteinemia increased significantly (p<0.01, p<0.05, respectively) and reached similar levels of CAPD patients with normohomocys teinemia, while plasma concentrations of total homocysteine decreased after folic acid supplementation. These findings suggest that correction of hyperhomocysteinemia in patients on dialysis produces an increase in unsaturated fatt acids.

Journal

• The Japanese Journal of Nephrology

  The Japanese Journal of Nephrology 40 (1), 8-16, 1998

  Japanese Society of Nephrology

Keywords

• hyperhomocysteinemia, folic acid, unsaturated fatty acid, CAPD

Details

• CRID: 1390001204857570432
• NII Article ID: 130004064212
• NII Article ID: 10008361978
• NII Book ID: AN10131749
• DOI: 10.14842/jpnjnephrol1959.40.8
• ISSN: 18840728
• ISSN: 03852385
• PubMed: 9513377
• Web Site: https://search.jamas.or.jp/link/ui/1998130676
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed