Effect of Probucol Treatment on Blood Lipid Markers(Especially Malondialdehyde-modified Low-density Lipoproteins) in Type 2 Diabetic Patients with Hypercholesterolemia.
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- Sato Noriyuki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kase Hiroyuki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Suzuki Manabu
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Iijima Hideo
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kawagoe Yoshiaki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Matsumura Mihoko
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Motohashi Satoshi
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Atsuta Haruhiko
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kato Tetsuya
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Mochizuki Yasuhiro
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kanazawa Hiroki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kuroda Hisamoto
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Bannba Nobuyuki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Hattori Yoshiyuki
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
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- Kasai Kikuo
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine
Bibliographic Information
- Other Title
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- プロブコール投与が高脂血症を合併した2型糖尿病患者の脂質代謝に及ぼす効果 特にMDA‐LDLの検討を中心として
- プロブコール トウヨ ガ コウシケツショウ オ ガッペイ シタ 2ガタ トウニョウビョウ カンジャ ノ シシツ タイシャ ニ オヨボス コウカ : トクニ MDA-LDL ノ ケントウ オ チュウシン ト シテ
- 特にMDA-LDLの検討を中心として
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Abstract
Probucol is known to have an antioxidant effect, but its effect on serum malondialdehyde-modified LDL (MDA-LDL) is unknown. We studied the effect of 3-month probucol treatment on MDA-LDL and other lipids markers [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipid peroxidation (LPO), lipoprotein a (Lp (a)), and remnant-like particle cholesterol (RLP-C)] in type 2 diabetic patients with hypercholesterolemia.<BR>At the start of treatment, MDA-LDL correlated positively with LPO, TC, LDL-C, and HbA1c (p<0.05). Probucol treatment significantly reduced MDA-LDL, LPO, TC, HDL-C, and LDL-C (p<0.05), although other markers were not changed. Furthermore, % change in MDA-LDL by probucol treatment also correlated positively with % changes in both LPO and HbAic.<BR>This data suggests that probucol reduced MDA-LDL in type 2 diabetic patients. Probucol is thus useful in improving dyslipidemia quantitatively and qualitatively in type 2 diabetic patients.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 45 (3), 199-204, 2002
THE JAPAN DIABETES SOCIETY
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Details
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- CRID
- 1390001204904756736
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- NII Article ID
- 10008362743
- 130004338834
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 025094862
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed