Sleep-Time Variation for Ethanol and the Hypnotic Drugs Tribromoethanol, Urethane, Pentobarbital, and Propofol within Outbred ICR Mice

この論文にアクセスする

この論文をさがす

著者

抄録

To evaluate the phenotypic variation within a commercial outbred mouse stock, we examined sleep-time (or duration of loss of righting reflex) of outbred ICR mice after i.p. injection of ethanol (4.0 g/kg of body weight), urethane (1.3 g), tribromoethanol (250 mg), and pentobarbital (60 mg), and after i.v. injection of propofol (30 mg). We observed high-grade individual differences in sleep-time that ranged from 0 to 179 min, 83.1 ± 4.3 (mean and SEM of 100 mice) for ethanol; 0 to 169 min, 64.5 ± 3.1 for pentobarbital; 0 to 160 min, 36.6 ± 3.6 for urethane; 0 to 120 min, 21.5 ± 2.2 for tribromoethanol; and 3 to 20.5 min, 7.1 ± 0.3 for propofol. This extensive phenotypic variance within the outbred stock was as great as the variation reported among inbred strains or selected lines, and the varied susceptibility within the colony was inherited by Jcl:ICR-derived inbred strains IAI, ICT, IPI, and IQI. The range of sleep-time variance for ethanol, pentobarbital, urethane, tribromoethanol, and propofol within four-way cross hybrid Jcl:MCH(ICR) mice was 86.6%, 63.3%, 124%, 61.0%, and 53.1% that of outbred Jcl:ICR mice, respectively. The present study indicates that phenotypic variance within an outbred Jcl:ICR stock was at high risk for susceptibility to the drugs that depress the central nervous system and that Jcl:ICR-derived inbreds may be an excellent source of animal models for studying the anesthesia gene.

収録刊行物

  • Experimental animals

    Experimental animals 51(2), 119-124, 2002-04

    Japanese Association for Laboratory Animal Science

参考文献:  26件中 1-26件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008394177
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13411357
  • NDL 記事登録ID
    6136297
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ