Genetic Polymorphism of Human Tissue Phenol Sulfotransferases.

• OZAWA Shogo

  Division of Pharmacology, National Institute of Health Sciences

• SHIMIZU Makiko

  Division of Pharmacology, National Institute of Health Sciences Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• MATSUMOTO Yoshiaki

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• FUKUOKA Masamichi

  Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University

• KATO Takahiko

  Department of Public Health, Miyazaki Medical College

• OHNO Yasuo

  Division of Pharmacology, National Institute of Health Sciences

Bibliographic Information

Other Title

• ヒト組織フェノール硫酸転移酵素の遺伝的多型性

Abstract

Three related forms of phenol sulfotransferase, thermostable ST1A2 and ST1A3 and a thermolabile ST1A5 are known to exist in human livers. Thermostable forms, whose activities are polymorphically distributed in human tissues, have been shown to mediate the bioactivation of carcinogenic N-hydroxy aromatic amines as well as phenolic substrates. Variant forms of ST1A3 mRNAs (i.e. Arg213His and Met223Val) have been found in human livers. In a Japanese population, allele frequencies of ²¹³Arg and ²¹³His were 0.83 and 0.17, respectively. No remarkable difference in [³⁵S]3'-phosphoadenosine 5'-phosphosulfate (PAPS)-dependent sulfation of p-nitrophenol was observed between recombinant ²¹³Arg- and ²¹³His-type ST1A3, although it was reported that ²¹³His homozygosity was associated with both lower (less than one-sevenths) p-nitrophenol sulfation and thermolability in human platelets. The recombinant ST1A3 (²¹³His) did exhibit unstability at 45° and 37°C as compared with ST1A3 (²¹³Arg). Liver cytosols from ²¹³His homozygotes did not always show low p-nitrophenol-sulfating activities. Different molecular mechanisms in sulfation polymorphism are suggested in livers and platelets of humans.

Journal

• Drug Metabolism and Pharmacokinetics

  Drug Metabolism and Pharmacokinetics 15 (2), 171-176, 2000

  The Japanese Society for the Study of Xenobiotics

Keywords

• Sulfotransferase
• Phenol sulfotransferase
• Human
• Liver
• Platelet
• Genetic polymorphism
• cDNA expression
• <I>E. coli</I>

Details

• CRID: 1390001204670260224
• NII Article ID: 10008416069
• NII Book ID: AN10144117
• DOI: 10.2133/dmpk.15.171
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/15/2/15_2_171/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000210227
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed