A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

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BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(1), 81-84, 2002-05-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008431136
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    6170965
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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