A Nuclear Factor-.KAPPA.B Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells.

• Ohkita Mamoru

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Takaoka Masanori

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Shiota Yasuko

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Nojiri Rumi

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Sugii Masato

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Matsumura Yasuo

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

Bibliographic Information

Other Title

• A Nuclear Factor-kB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells
• A Nuclear Factor-κdB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells
• A nuclear factor-κB inhibitor BAY 11-7082 suppresses endothelin-1 production in cultured vascular endothelial cells
• A nuclear factor-κB inhibitor BAY 11‐7082 suppresses endothelin-1 production in cultured vascular endothelial cells

Abstract

BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 89 (1), 81-84, 2002

  The Japanese Pharmacological Society

Keywords

• Nuclear factor-κB
• Endothelin-1
• Tumor necrosis factor-α

Details

• CRID: 1390282679262704128
• NII Article ID: 10008431136
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.89.81
• COI: 1:STN:280:DC%2BD38zktFSlsA%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 6170965
• PubMed: 12083747
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6170965
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819301507?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819301507?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2002259374
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed