Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats

この論文にアクセスする

この論文をさがす

著者

抄録

The role of metabotropic glutamate receptor (mGluR) on dopamine overflow from the striatum was studied in methamphetamine (MAP)-sensitized rats. The increase of dopamine release by MAP was significantly inhibited by perfusion of a mGluR antagonist <i>R</i>,<i>S</i>-α-methyl-4-carboxyphenylglycine. The perfused mGluR agonist 1<i>S</i>,3<i>R</i>-1-aminocyclopentane-1,3-dicarboxylic acid enhanced the dopamine level. The enhancement was significantly attenuated by co-perfusion of a mGluR group I antagonist (<i>S</i>)-4-carboxy-3-hydroxyphenylglycine or a mGluR group II antagonist <i>R</i>,<i>S</i>-α-methyl-4-tetrazolylphenylglycine. These suggest that both mGluR group I and II mediate augmentation of dopamine release in MAP-sensitized rats.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(1), 85-88, 2002-05-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008431152
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    6170983
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ