Modulation by 5-HT_<2A> Receptors of Aggressive Behavior in Isolated Mice

この論文にアクセスする

この論文をさがす

著者

抄録

The present study examines whether isolation-rearing affects sensitivity of 5-hydroxytryptamine (5-HT)<sub>2A</sub> receptors and the functional interaction between 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors in mice. The 5-HT<sub>2A</sub>-receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch response was significantly greater in isolated mice than in grouped mice. DOI increased isolation-induced aggressive behavior, and the 5-HT<sub>2A</sub>-receptor antagonist ritanserin decreased it. The 5-HT<sub>1A</sub>-receptor agonist (<i>S</i>)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242) inhibited the DOI-enhanced aggressive behavior. MKC-242 inhibited DOI-induced head twitch response. These findings suggest that 5-HT<sub>2A</sub> receptors play a role in aggressive behavior in isolated mice and imply that the antiaggressive effect of MKC-242 may be mediated partly by the inhibition of 5-HT<sub>2A</sub>-receptor function.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(1), 89-92, 2002-05-01

    The Japanese Pharmacological Society

参考文献:  14件中 1-14件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008431168
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    6171034
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ