AN INVESTIGATION OF PERIOPERATIVE IMMUNOSUPRESSION IN PATIENTS WITH GASTRIC AND ESOPHAGEAL CARCINOMA IN TERMS OF EXPRESSION OF SURFACE ANTIGEN HLA-DR ON MONOCYTES AND SERUM IL-6 AND IL-8 LEVELS

• NAKASE Hajime

  First Department of Surgery, Yamanashi Medical College

• KONO Koji

  First Department of Surgery, Yamanashi Medical College

• SEKIKAWA Takayoshi

  First Department of Surgery, Yamanashi Medical College

• MATSUMOTO Yoshiro

  First Department of Surgery, Yamanashi Medical College

Bibliographic Information

Other Title

• 末梢血単球表面抗原発現率と血清IL-6, IL-8の値による担癌患者の周術期における免疫能の評価

Abstract

We investigated the perioperative changes in immunological function of monocytes in patients with gastric or esophageal carcinoma in terms of surface antigen HLA-DR and serum cytokine IL-6 and IL-8 levels. Subjects were 16 cases of curatively resected gastric carcinoma, seven cases of non-curatively resected gastric carcinoma, three cases of curatively resected and four cases of non-curatively resected esophageal carcinoma. Six cases received laparoscopic cholecystectomy for cholecystolithiasis were served as control. Peripheral blood samples were collected from them on the day before operation, 1st, 3rd, 5th, 7th and 14th postoperative day. Of these samples, the mean fluorescence intensity (MFI) of surface antigen HLA-DR expressed on monocytes were analyzed by FACScan, and serum cytokines were analyzed by ELISA.<br> In patients with gastric carcinoma no significant difference in the MFI of HLA-DR was noted between curatively resected and noncuratively resected groups, but in noncuratively resected group it was significantly lower on 14th postoperative day than that of preoperative day. In patients with esophageal carcinoma, there was no significant difference in the MFI of HLA-DR between curatively resected and noncuratively resected groups on the preoperative day, but in curatively resected group it significantly increased on the 3rd postoperative day. Serum IL-8 level in noncuratively resected gastric carcinoma group was significantly higher than those of curatively resected group on preoperative day and the 1st postoperative day. Serum IL-8 level in noncuratively resected esophageal carcinoma group was significantly higher than that of curatively resected group in perioperative period.<br> These results suggest that patients with noncuratively resected esophageal carcinoma have fallen into the state of immunosupression of monocytes.

Journal

• Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 59 (4), 901-907, 1998

  Japan Surgical Association

Keywords

• HLA-DR
• IL-6
• IL-8

Details

• CRID: 1390001204848855040
• NII Article ID: 130003600914
• NII Article ID: 10008435484
• NII Book ID: AA11189709
• DOI: 10.3919/jjsa.59.901
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/ringe1998/59/4/59_4_901/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998217979
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed