Acromegalic Gigantism with Low Serum Level of Growth Hormone and Elevated Serum Insulin-Like Growth Factor-I

この論文にアクセスする

この論文をさがす

著者

    • MIYAZAKI Reiko
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • YOSHIDA Toshihide
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • SAKANE Naoki
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • YASUDA Tomoko
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • UMEKAWA Tsunekazu
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • KONDO Motoharu
    • The First Department of Internal Medicine, Kyoto Prefectural University of Medicine
    • SHIMATSU Akira
    • The Second Division, the Department of Medicine, Kyoto University Faculty of Medicine
    • HIZUKA Naomi
    • The Second Department of Internal Medicine, Tokyo Women's Medical College
    • SANO Toshiaki
    • The First Department of Pathology, Tokushima University School of Medicine

抄録

In a case of acromegalic gigantism with hyperprolactinemia is reported, the basal serum growth hormone (GH) levels ranged from 1.2 to 1.9 ng/ml. Serum GH response to either insulin-induced hypoglycemia or GH-releasing hormone was blunted. Frequent blood sampling showed non-pulsatile GH secretion. Serum prolactin and insulin-like growth factor-I (IGF-I) levels were elevated. After unsuccessful surgery, bromocriptine treatment normalized serum prolactin without affecting serum GH and IGF-I levels. Combined administration of octreotide with bromocriptine reduced serum GH and IGF-I levels. In this case, non-pulsatile GH secretion and enhanced tissue sensitivity to GH may induce hypersecretion of IGF-I and cause clinical acromegalic gigantism.<br>(Internal Medicine 34:183-187, 1995)

収録刊行物

  • Internal medicine

    Internal medicine 34(3), 183-187, 1995-03-01

    The Japanese Society of Internal Medicine

参考文献:  11件中 1-11件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

ページトップへ