Acromegalic Gigantism with Low Serum Level of Growth Hormone and Elevated Serum Insulin-Like Growth Factor-I.

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  • MIYAZAKI Reiko
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • YOSHIDA Toshihide
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SAKANE Naoki
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • YASUDA Tomoko
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • UMEKAWA Tunekazu
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • KONDO Motoharu
    the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SHIMATSU Akira
    the Second Division, the Department of Medicine, Kyoto University Faculty of Medicine
  • HIZUKA Naomi
    the Second Department of Internal Medicine, Tokyo Women's Medical College
  • SANO Toshiaki
    the First Department of Pathology, Tokushima University School of Medicine

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Abstract

In a case of acromegalic gigantism with hyperprolactinemia is reported, the basal serum growth hormone (GH) levels ranged from 1.2 to 1.9 ng/ml. Serum GH response to either insulin-induced hypoglycemia or GH-releasing hormone was blunted. Frequent blood sampling showed non-pulsatile GH secretion. Serum prolactin and insulin-like growth factor-I (IGF-I) levels were elevated. After unsuccessful surgery, bromocriptine treatment normalized serum prolactin without affecting serum GH and IGF-I levels. Combined administration of octreotide with bromocriptine reduced serum GH and IGF-I levels. In this case, non-pulsatile GH secretion and enhanced tissue sensitivity to GH may induce hypersecretion of IGF-I and cause clinical acromegalic gigantism.<br>(Internal Medicine 34:183-187, 1995)

Journal

  • Internal Medicine

    Internal Medicine 34 (3), 183-187, 1995

    The Japanese Society of Internal Medicine

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