Variability in Cholesteryl Ester Transfer Protein in Healthy Japanese Hyper-HDL-cholesterolemic Subjects

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<i>Objective</i> Hyper-high density lipoprotein (HDL)-cholesterolemia has been considered to be anti-atherogenic and is referred to as longevity syndrome. However, hyper-HDL-cholesterolemia induced by a cholesteryl ester transfer protein (CETP) deficiency may not be athero-protective, rather being atherogenic in nature. In a rural area in central Japan, the incidence of hyper-HDL-cholesterolemia has been found to be rather high (3.1% of healthy people). We studied healthy Japanese people in this area with hyper-HDL-cholesterolemia, particularly in relation to CETP.<br><i>Methods</i> Serum lipids were analyzed, and CETP mass was determined with an enzyme immunoassay method.<br><i>Materials</i> Blood was drawn after an overnight fast from 17 Japanese (5 males and 12 females) with serum HDL-cholesterol (C) ≥100 mg/dl.<br><i>Results</i> Serum CETP mass in hyper-HDL-cholesterolemic subjects was distributed in a wide range. Serum CETP mass was positively correlated with low-density lipoprotein (LDL)-C, apolipoprotein (Apo) B, and LDL-C/HDL-C, with statistical significance. CETP was also positively correlated with LDL-C/Apo B.<br><i>Conclusion</i> These results suggest that hyper-HDL-cholesterolemia may not be a single clinical entity, but a mixture of various pathophysiological conditions, and that the ratio of LDL-C to HDL-C and the size of LDL may be important factors in classifying these conditions.<br>(Internal Medicine 41: 357-359, 2002)

収録刊行物

  • Internal medicine

    Internal medicine 41(5), 357-359, 2002-05-01

    The Japanese Society of Internal Medicine

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各種コード

  • NII論文ID(NAID)
    10008450688
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    6169504
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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