YEARLY CHANGES IN ANTIBACTERIAL ACTIVITIES OF CEFOZOPRAN AGAINST VARIOUS CLINICAL ISOLATES BETWEEN 1996 AND 2000

• SUZUKI YUMIKO

  Section of Studies, Tokyo Clinical Research Center

• NISHINARI CHISATO

  Section of Studies, Tokyo Clinical Research Center

• ENDO HARUMI

  Section of Studies, Tokyo Clinical Research Center

• TAMURA CHIEKO

  Section of Studies, Tokyo Clinical Research Center

• JINBO KEIKO

  Section of Studies, Tokyo Clinical Research Center

• HIRAMATSU NOBUYOSHI

  Postmarketing Surveillance Department Pharmaceutical Development Division, Takeda Chemical Industries, LTD.

• AKIYAMA KAZUMITSU

  Postmarketing Surveillance Department Pharmaceutical Development Division, Takeda Chemical Industries, LTD.

• KOYAMA TSUNEO

  Postmarketing Surveillance Department Pharmaceutical Development Division, Takeda Chemical Industries, LTD.

Bibliographic Information

Other Title

• 臨床分離株に対するcefbzopranの抗菌力の推移 (1996-2000年)
• I. GRAM-POSITIVE BACTERIA
• その1 グラム陽性菌

Abstract

The in vitro antibacterial activities of cefozopran (CZOP), an agent of cephems, against various clinical isolates obtained between 1996 and 2000 were yearly evaluated and compared with those of other cephems, oxacephems, carbapenems, and penicillins. Fifteen species, 1,062 strains, of Gram-positive bacteria were isolated from the clinical materials annually collected from January to December, and consisted of methicillin-susceptible Staphylococcus aureus (MSSA; n=127), methicillin-resistant Staphylococcus aureus(MRSA; n=123), Staphylococcus epidermidis (n=104), Staphylococcus haemolyticus (n=58), Streptococcus pyogenes (n=100), Streptococcus agalactiae (n=50), Streptococcus pneumoniae (n=125), Enterococcus faecalis (n=150), Enterococcus faecium (n=50), Enterococcus avium (n=50), and Peptostreptococcus spp.(P. anaerobius, P. asaccharolyticus, P. magnus, P. micros, P. prevotii; n=125). CZOP possessed stable antibacterial activities against all strains tested throughout 5 years. The MIC₉₀ of CZOP against MRSA and S. haemolyticus tended to decrease while against S. pneumoniae and Peptostreptococcus spp., tended to increase year by year. However, the MIC₉₀ just changed a little and were consistent with the results from the studies performed until the new drug application approval. Increases in the MIC₉₀ against S. pneumoniae were also observed with cefpirome (CPR), cefepime (CFPM), flomoxef (FMOX), sulbactam/cefoperazone (SBT/CPZ), and imipenem (IPM). Increases in the MIC₉₀ against Peptostreptococcus spp. were also observed with ceftazidime (CAZ), CPR, CFPM, FMOX, SBT/CPZ, and IPM. The decreases in the sensitivities were not always considered to depend upon generation of resistant bacteria because the annual MIC range of each antibacterial agent was almost generally wide every year and the annual sensitivity of each strain to the agents extremely varied.<BR>In conclusion, the annual antibacterial activities of CZOP against the Gram-positive bacteria did not considerably change. It, therefore, was suggested that CZOP had maintained high antibacterial activity during 5 years of post-marketing.

Journal

• The Japanese Journal of Antibiotics

  The Japanese Journal of Antibiotics 55 (2), 139-153, 2002

  Japan Antibiotics Research Association

Details

• CRID: 1390001205494096512
• NII Article ID: 10008465490
• NII Article ID: 130004395925
• NII Book ID: AN00002626
• DOI: 10.11553/antibiotics1968b.55.139
• COI: 1:STN:280:DC%2BD38zivVKrsw%3D%3D
• ISSN: 21865477
• ISSN: 03682781
• PubMed: 12071093
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed