Novel Cytokine Production Inhibitors Produced by a Basidiomycete, Marasmiellus sp.

• ICHIKAWA KATSUOMI

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• HIRAI HIDEO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• ISHIGURO MASARU

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• KAMBARA TAKAHITO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc. Present address: The Queen's Veterinary School Hospital, University of Cambridge

• KATO YOSHINAO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• KIM YOON JEONG

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• KOJIMA YASUHIRO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• MATSUNAGA YASUE

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• NLSHIDA HLROYUKI

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• SHIOMI YUKIO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc. Business Intelligence Department, Pfizer Pharmaceuticals Inc.

• YOSHIKAWA NOBUJI

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.

• KOJIMA NAKAO

  Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc. Faculty of Pharmacy, Meijo University

Abstract

New cytokine production inhibitors, CJ-14, 877 (I) and CJ-14, 897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7R, 8S)-5-(7, 8-dihydroxypropyl)pyridine-2-carboxylate and methyl(7R, 8S)-5-(8-acetoxy-7-hydroxypropyl)pyridme-2-carboxylate, respectively, by spectroscopic analyses. These compounds showed inhibitory activities for lipopolysaccharide-induced production of interleukin-1β and tumor necrosis factor-a in human whole blood with IC₅₀ values of the range from 0.059 to 2.6 JUM.

Journal

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (9), 703-709, 2001

  JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1390282679125877376
• NII Article ID: 130003410427
• NII Article ID: 10008470833
• NII Book ID: AA0069330X
• DOI: 10.7164/antibiotics.54.703
• COI: 1:CAS:528:DC%2BD3MXnt1elu7Y%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 11714225
• Web Site: https://search.jamas.or.jp/link/ui/2002096673
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed