Biosynthesis of the Thiazolylpeptide Antibiotic GE2270.

• PIETRO MARIA TERESA DE

  Biosearch Italia SpA

• MARAZZI ALESSANDRA

  Biosearch Italia SpA

• SOSIO MARGHERITA

  Biosearch Italia SpA

• DONADIO STEFANO

  Biosearch Italia SpA

• LANCINI GIANCARLO

  Biosearch Italia SpA

Abstract

The biosynthesis of the antibiotic GE2270 in the producing microorganism Planobispora rosea was investigated by adding labelled amino acid precursors. Efficient incorporation of glycine and serine was observed, leading to specific enrichments of selected positions of the thiazole, oxazoline and pyridine rings. Furthermore, efficient enrichment of the C-, N- and O-methyl groups was detected. These results indicate that GE2270 is made through a biosynthetic route similar to that determined for other thiazolylpeptides. At the same time, the result point to an efficient route for the conversion of glycine into serine and methyl equivalents in Planobispora rosea.

Journal

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (12), 1066-1071, 2001

  JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1390282679127723136
• NII Article ID: 10008471634
• NII Book ID: AA0069330X
• DOI: 10.7164/antibiotics.54.1066
• COI: 1:CAS:528:DC%2BD38XhtF2lsA%3D%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 11858662
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed