SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis. III. Immunosuppressive Efficacy.
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- KUROSAWA KAZUHIKO
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. National Food Research Institute
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- TAKAHASHI KOSAKU
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. National Food Research Institute
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- FUJISE NOBUAKI
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- YAMASHITA YASUSHI
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- WASHIDA NAOHIRO
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. Daiichi Pharmaceutical Co., Ltd.
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- TSUDA EISUKE
- Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. Biological Research Laboratories, Sankyo Co., Ltd.
書誌事項
- タイトル別名
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- III. Immunosuppressive Efficacy
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抄録
Novel immunosuppressants, SNF4435C and D produced by a strain of Streptomyces spectabilis, were examined for their pharmacodynamical profiles. SNF4435C and D suppressed the responses of both murine splenocytes and human peripheral blood lymphocytes in the mixed lymphocyte reaction (MLR) with IC50 values of 0.5μM and 0.2μM, respectively. In the mouse MLR experiments, SNF4435C and D did not block the production of interleukin-2 (IL-2) and the compounds-induced suppression was not restored by the addition of exogeneous IL-2. In addition, the significant inhibitory action was still retained even when SNF4435C or D was added after 48 hours from the start of the culture. These results were distinct from the behaviors observed with FK-506. SNF4435C, the major component, suppressed mouse delayed type hypersensitivity (DTH) and prolonged rat skin allograft survival.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 55 (1), 71-77, 2002
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390282679125492224
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- NII論文ID
- 130003503915
- 10008471833
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DC%2BD38Xos1CnsQ%3D%3D
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- ISSN
- 18811469
- 00218820
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- PubMed
- 11918069
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可