癌集学的治療を行った甲状腺未分化癌の1例

• 大西 博信

  和歌山県立医科大学第2外科

• 谷村 弘

  和歌山県立医科大学第2外科

• 山上 裕機

  和歌山県立医科大学第2外科

書誌事項

タイトル別名

• MULTIDISCIPLINARY TREATMENT FOR A PATIENT WITH UNDIFFERENTIATED THYROID CANCER

抄録

The prognosis of undifferentiated thyroid cancer is extremely poor, and usual postoperative adjuvant therapies including chemotherapy and radiotherapy are almost ineffective. We have given anticancer drugs to such a patient according to the results of chemosensitivity test (SDI method) using highly purified (90%) tumor cells. A 73-year-old woman was admitted to the hospital because of a tumor on the right side of the neck. With a diagnosis of undifferentiated thyroid cancer based on a biopsy, a complete thyroidectomy and lymph nodes dissection were performed. Further extensive surgery was employed for a recurrence. From the excised material, tumor cells were purified up to 90%, for which SDI method was conducted. CDDP and ADM showed higher inhibition rates than other chemotherapeutics. Therefore, intravenous administration of 60mg/m² of CDDP on the day 1 followed by 40mg/m² of ADM on the day 4 was designated as one course; and four courses a month were given to the patient for three months. The patient survived for 11 months af-ter the initial operation.<br>It is suggested that appropriate chemotherapeutics selected according to the results of chemosensitivity testing may contribute to improve the prognosis of patients with undifferentiated thyroid cancer.

収録刊行物

• 日本臨床外科学会雑誌

  日本臨床外科学会雑誌 60 (8), 2051-2056, 1999

  日本臨床外科学会

キーワード

• 甲状腺未分化癌
• 集学的治療
• 抗癌剤感受性試験

詳細情報

• CRID: 1390282679829347072
• NII論文ID: 130003601478
• NII論文ID: 10008495978
• NII書誌ID: AA11189709
• DOI: 10.3919/jjsa.60.2051
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/ringe1998/60/8/60_8_2051/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000031785
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