書誌事項
- タイトル別名
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- Nitric Oxide-dependent Inhibition of Platelet Aggregation in Elderly Patients with Hypercholesterolemia.
- ロウネンシャ コウシケツショウ ニ オケル NO イゾンセイ ケッショウバン ギョウシュウ ヨクセイ ノ イジョウ
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抄録
Hypercholesterolemia reduces production of nitric oxide (NO), a potent inhibitor of platelet aggregation, in endothelial cells. Recently platelet has been found to have NO synthase. Hypercholesterolemia may influence platelet NO production. We investigated NO-dependent inhibition of platelet aggregation in elderly hypercholesterolemic patients with total cholesterol (Tchol) of 240mg/dl or more (n=21). In elderly controls with Tchol less than 240mg/dl (n=61), L-arginine (5-50mM) inhibited ADP-induced platelet aggregation in a dose-dependent manner (42.4% inhibition at 50mM). However, L-arginine did not inhibit platelet aggregation in elderly hypercholesterolemic patients. L-arginine increased cyclic GMP production in elderly controls, but not in hypercholesterolemic patients (p<0.02). Hypercholesterolemic patients showed increased platelet aggregation compared with elderly controls (p=0.018). L-nitro-arginine methyl ester 12.5-50uM increased platelet aggregation in both groups. Superoxide dismutase improved L-arginine inhibition of platelet aggregation in elderly hypercholesterolemic patients (p=0.02). LDL cholesterol of 160mg/dl or more was an independent predictor for loss of L-arginine inhibition of platelet aggregation (relative risk 3.9, p=0.0098). This result suggests that hypercholesterolemia causes decreased NO-dependent inhibition of platelet aggregation due to reduced NO utilization. NO-dependent platelet aggregation may be a powerful tool for detection of vascular injury.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 38 (2), 177-184, 2001
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205023045888
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- NII論文ID
- 130003652716
- 10008506470
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- NII書誌ID
- AN00199010
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- NDL書誌ID
- 5724970
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- ISSN
- 03009173
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- PubMed
- 11305031
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可