IMMUNOHISTOCHEMICAL STUDY OF S100α AND S100β SUBUNITS IN BREAST TUMORS

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  • OIKE Eko
    Department of Surgery II, Nagoya University School of Medicine
  • KOSHIKAWA Takashi
    Department of Pathology and Clinical Laboratories, Aichi Cancer Center
  • FUNAHASHI Hiroomi
    Department of Surgery II, Nagoya University School of Medicine
  • IMAI Tsuneo
    Department of Surgery II, Nagoya University School of Medicine
  • TANAKA Yuji
    Department of Surgery II, Nagoya University School of Medicine
  • TOBINAGA Junichi
    Department of Surgery II, Nagoya University School of Medicine
  • MORITA Takako
    Department of Surgery II, Nagoya University School of Medicine
  • WADA Masaki
    Department of Surgery II, Nagoya University School of Medicine
  • TAKAGI Hiroshi
    Department of Surgery II, Nagoya University School of Medicine
  • ASAI Junpei
    Department of Pathology I, Nagoya University School of Medicine
  • KATO Kanefusa
    Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony

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Other Title
  • 乳腺腫瘍におけるS100αおよびS100βサブユニットの免疫組織化学的検討

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Abstract

Using anti-S100α and S100β antibodies without any cross reactivity which were purified by affinity chromatography, an immunohistochemicalstudy was conducted on 72 benign breast lesions (from 34 cases of mastopathy and38 cases of fibroadenoma) and 72 malignant breast lesions (invasive ductal carcinoma). Both S100α- and S100β-positive cells occupied more than 30% of proliferation in all the benign lesions. On the other hand, malignant lesion with S100α-positive cells occupied more than 30% of proliferation was confirmed in 70 cases (97.2%), but the lesion with S100β-positive cells in more than 30% of occupation rate was found only in 3 cases (4.2%). These findings indicate that there is a decreasing tendency of S100β-positive cells in breastcancers.<br> We think that this exploration using such very specific antibodies capable of clarifying hidden findings from usual antibody tests can be an adjuvantexamination for breast lesions which present difficulty in differential diagnosis only by HE staining.

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