一側多発乳癌6例の臨床病理学的検討 : 乳房温存手術の適応との関連において SIX CASE OF BREAST CANCER WITH GROSS MULTIPLE TUMORS

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乳房温存療法施行の際に,温存乳房に多発癌が潜む危険性の高い症例の特徴を明らかにするため,切除標本割面にて2個以上の腫瘤を認めた一側多発乳癌症例を対象に,主,副病巣の組織像および背景組織像を中心に臨床病理学的検討を行った.多発癌の頻度は6/98例(6.1%)であり,副病巣の発生機序は,乳管内進展型が5例(83.3%), 多中心性発生型が1例(16.7%)で,乳腺内転移型は認めなかった.乳管内進展型を示した5例の組織型は,いずれも非浸潤性乳管癌あるいは乳頭腺管癌であり,そのうち2例はcomedo typeであった.癌周囲の背景組織は, 3例(50.0%)に良性疾患が存在し,そのうち2例がatypical hyperplasiaを呈していた.乳房温存療法を行う上で,乳管内進展傾向,組織型, comedoの存在,癌周囲の背景組織の検索は,癌遺残の原因となる多発癌の存在を示唆する手がかりになると考えられた.

To identify the characteristics indicative of involvement of occult tumors in the remnant breast on breast conservative surgery, we clinicopathologically examined the breast tumors and tissues surrounding the tumors in unilateral breast cancer with gross multiple tumors at the surgical specimen. Gross multiple tumor was found in 6 out of 98 cases of primary breast cancer (6.1%). Of these 6 cases, 5 cases (83.3%) were classified as intraductal spreading type, 1 case (16.7%) as multicentric type, and none as intramammary metastatic type. Histological type of 5 cases showing intraductal spreading type was either non-invasive intraductal cracinona or papillotubular carcinoma, and in 2 cases of them, component of comedo was found. Additionally, in the tissues surrounding tumors, benign breast diseases were found in 3 cases (50.0%), including atypical hyperplasia in 2 cases. We think that it is useful to know the degree of intraductal spreading, histological type of tumors, existence of comedo component and pathological features of tissues surrounding the tumors for predicting the existence of the occult tumors in the remnant breast on breast conservative surgery.

収録刊行物

  • 日本臨床外科医学会雑誌 = The journal of the Japanese Practical Surgeon Society

    日本臨床外科医学会雑誌 = The journal of the Japanese Practical Surgeon Society 57(4), 829-834, 1996-04-25

    Japan Surgical Association

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各種コード

  • NII論文ID(NAID)
    10008520352
  • NII書誌ID(NCID)
    AN00198696
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    03869776
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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