高齢者胃癌症例の臨床病理学的検討

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  • CLINICOPATHOLOGICAL EVALUATION OF SENILE PATIENTS WITH GASTRIC CANCER

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In order to clarify the characteristics of gastric cancers in senile patients over 75 years old, clinicopathological factors were compared between senile patients and middle aged patients (55 to 65 years old) with gastric cancer. There were 118 (19.7%) senile patients and 190 (31.7%) middle aged patients. No significant difference was noted in the male-to-female ration, resectability, curative resectability, lymph node disection, site of cancer and extent of lymph node metastasis between the two groups. There were significant difference in the macroscopic type, histological classification and histological stage between them. The number of preoperative complications in senile patients was 84 (71.2%) and that in middle aged patients was 109 (57.4%) with a significant difference. The most common disease was respiratory disease followed by cardiovascular disease and hypoproteinemia in the senile patients. The incidences of these disease were significantly higher than those in the middle aged patients. The incidence of postoperative complications was significantly different between the two groups, too. Futhermore, no correlation was found between the incidence of preoperative complications and the occurrence of postoperative morbidity. The duration of surgery and the bleeding volume in senile patients with postoperative complication were significantly greater than those without complication. The 5-year suvival rates in the senile patients with more than 120 minutes of duration of surgery and 400ml of bleeding volume were tendency to be worse. The 5-year survival rate was not significantly related with age, presence of preoperative complication, occurrence of postoperative morbidity, histological type or conclusive stage grouping between them. To improve the prognosis of senile patients with gastric cancer, appropriate less invasive surgery such as D1+α dissection must be selected and intensive therapy, especially for pneumonia, should be carried out during the pre-and postoperative periods.

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