乳癌における予後因子としてのKi-67値の臨床病理学的検討

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  • Ki-67 SCORE IN BREAST CARCINOMA DETERMINED BY IMMUNOSTAINING AND ITS RELATIONSHIP TO CLINICAL AND PATHOLOGICAL PROGNOSTIC FACTORS

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In 60 parients with primary breast cancer, immunohistochemical staining of the tumor cells was conducted using a monoclonal antibody Ki-67, and their Ki-67 scores (positive cells/total tumor cells) were determined to clarify relationships between clinicopathological factors, recurrence, p53 (mutant type), estrogen receptor level and prognosis. Ki-67 recognizes a nuclear antigen expressed by cells in G1, S, G2 and M phases of the cess cycle but not G0. Ki-67 scores of the breast carcinomas distibuted from 3% to 62%, with an average of 26.6%.<br> There were strong correlations between the Ki-67 score and recurrence (p<0.01), p53 positive (p<0.01), and ER negative (p<0.05). No relationship was noted between the Ki-67 score and clinical stage, tumor size, lymph node status and histological type.<br> The Ki-67 score might prove to be a new independent prognostic indecator of biological behavior of breast cancer and thus be of clinical significance, since the variable is greatly unrelated to other clinicopathological parameters.

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