書誌事項
- タイトル別名
-
- Ki-67 SCORE IN BREAST CARCINOMA DETERMINED BY IMMUNOSTAINING AND ITS RELATIONSHIP TO CLINICAL AND PATHOLOGICAL PROGNOSTIC FACTORS
この論文をさがす
抄録
In 60 parients with primary breast cancer, immunohistochemical staining of the tumor cells was conducted using a monoclonal antibody Ki-67, and their Ki-67 scores (positive cells/total tumor cells) were determined to clarify relationships between clinicopathological factors, recurrence, p53 (mutant type), estrogen receptor level and prognosis. Ki-67 recognizes a nuclear antigen expressed by cells in G1, S, G2 and M phases of the cess cycle but not G0. Ki-67 scores of the breast carcinomas distibuted from 3% to 62%, with an average of 26.6%.<br> There were strong correlations between the Ki-67 score and recurrence (p<0.01), p53 positive (p<0.01), and ER negative (p<0.05). No relationship was noted between the Ki-67 score and clinical stage, tumor size, lymph node status and histological type.<br> The Ki-67 score might prove to be a new independent prognostic indecator of biological behavior of breast cancer and thus be of clinical significance, since the variable is greatly unrelated to other clinicopathological parameters.
収録刊行物
-
- 日本臨床外科医学会雑誌
-
日本臨床外科医学会雑誌 58 (1), 1-7, 1997
日本臨床外科学会
- Tweet
詳細情報
-
- CRID
- 1390282680291372928
-
- NII論文ID
- 130003600151
- 10008525860
-
- NII書誌ID
- AN00198696
-
- ISSN
- 21892075
- 03869776
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可