乳腺T cell lymphomaの1例 A CASE OF T CELL MALIGNANT LYPHOMA OF THE BREAST

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症例は84歳女性,左乳房腫瘤を主訴に来院,左乳房DCE領域に4.3×4.3cmの球形,境界明瞭,表面平滑な弾性硬の腫瘤を認め,マンモグラフィー,エコーで乳癌が強く疑われたため手術目的で入院した.鹿児島県出生在住でHTLV-1抗体が陽性であった.<br> 病理検索で腫瘍はlymphoid cellの増殖よりなり, mediumからlarge cellが混在していた.分裂像も散見され核異型も著明であった.腫瘍細胞の核クロマチンは粗造不規則で,深い切れ込みを認めhyperconvoluted patternを示していた.免疫染色の結果はPan T, UCHL1が陽性であり, Pan B, L26はほとんど染まらなかった.以上よりmalignant lymphoma, diffuse, pleomorphictype, T cell typeと診断した.当症例は,抗HTLV-1抗体陽性のTリンパ腫でありATLのリンパ腫型が最も考えられた.乳腺に発生するT cell由来の悪性リンパ腫はきわめてまれであり当症例は本邦で4例目である.

An 84-year-old woman was seen at the hospital because of a lump of her left breast. There was a firm and sharply bordered mass measured 4.3×4.3cm in size in the DCE area of the left breast. She was strongly suspected to have a breast cancer with mammography and echography. She was living in Kagoshima Prefecture, and HTLV-1 Ab was positive.<br> Pathologically, the tumor consisted of proliferation of lymphoid cells, and medium to large cells coexisted. Mitotic figure was observed commonly, and pleomorphism of the nuclei was prominent. Chromatins of the nuclei of the tumor cell were coarse and irregular and revealed hyperconvoluted pattern. In the immunohistochemical staining, tumor cell was positive with PanT UCHL1 and negative with PanB L26. It was diagnosised as malignant lymphoma, diffuse, pleomorphic type, T cell type. This case was HTL-1 Ab positive, and lymphoma type of the ATL was most probable. T cell lymphoma of the breast is very rare, this is the 4th report in Japan so far.

収録刊行物

  • 日本臨床外科医学会雑誌 = The journal of the Japanese Practical Surgeon Society

    日本臨床外科医学会雑誌 = The journal of the Japanese Practical Surgeon Society 58(1), 85-89, 1997-01-25

    Japan Surgical Association

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各種コード

  • NII論文ID(NAID)
    10008526114
  • NII書誌ID(NCID)
    AN00198696
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    03869776
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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