PREOPERATIVE MORPHOMETRIC APPROACH FOR THE DIAGNOSIS OF FOLLICULAR CARCINOMA OF THE THYROID

• NAGASHIMA Takeshi

  First Department of Surgery, Chiba University School of Medicine

• SUZUKI Masato

  First Department of Surgery, Chiba University School of Medicine

• OSHIDA Masaki

  First Department of Surgery, Chiba University School of Medicine

• HASHIMOTO Hideyuki

  First Department of Surgery, Chiba University School of Medicine

• YAGATA Hiroshi

  First Department of Surgery, Chiba University School of Medicine

• KODA Keiji

  First Department of Surgery, Chiba University School of Medicine

• NAKAJIMA Nobuyuki

  First Department of Surgery, Chiba University School of Medicine

Bibliographic Information

Other Title

• 術前客観的核異型度計測による甲状腺濾胞癌の診断

Abstract

The present study was carried out to evaluate the preoperative quantitative estimations of various nuclear features which were obtained by means of fine-needle aspiration biopsies, for the diagnosis of follicular carcinoma of the thyroid. Subjects were 48 patients with follicular tumor of the thyroid operated on at the hospital between November 1987 and December 1994, whose histological explorations were fully conducted. Morphometric parameters including nuclear area, nuclear perimeter, circular rate, the largest to the smallest diameter ratio (LS) and coefficient of variation in nuclear area (NACV) were measured and calculated in aspirated cytological smears obtained from the patients with follicular tumor of the thyroid (18 follicular carcinomas, 13 adenomas and 17 adenomatous goiters). All parameters were estimated in at least 100 nuclei per case, and the results were analysed statistically. The circular rate of nuclei from adenomatous goiters was significantly greater than follicular carcinomas (p<0.001) and adenomas (p<0.05). LS of follicular carcinomas was significantly greater than adenomatous goiters (p<0.05). NACV showed significant differences between any of the groups (p<0.001).<br> In conclusion, preoperative quantitative estimations of cytological nuclear features are of great help concerning differential diagnosis of follicular tumors of the thyroid.

Journal

• The journal of the Japanese Practical Surgeon Society

  The journal of the Japanese Practical Surgeon Society 58 (2), 275-279, 1997

  Japan Surgical Association

Keywords

• 甲状腺腫瘍
• 濾胞癌
• 鑑別診断
• 核異型度
• 穿刺吸引細胞診

Details

• CRID: 1390282680291383808
• NII Article ID: 130003600354
• NII Article ID: 10008526571
• NII Book ID: AN00198696
• DOI: 10.3919/ringe1963.58.275
• ISSN: 21892075
• ISSN: 03869776
• Web Site: http://www.jstage.jst.go.jp/article/ringe1963/58/2/58_2_275/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997152014
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed