Rapidly Progressive Renal Failure Occurring in the Course of Pyoderma Gangrenosum and IgA (.LAMBDA.) Monoclonal Gammopathy.

• AKATSUKA Toshio

  Internal Medicine II, Hokkaido University, School of Medicine

• KAWATA Tetsuya

  Internal Medicine II, Hokkaido University, School of Medicine

• HASHIMOTO Seiji

  Internal Medicine II, Hokkaido University, School of Medicine

• NAKAMURA Sakurako

  Internal Medicine II, Hokkaido University, School of Medicine

• KOIKE Takao

  Internal Medicine II, Hokkaido University, School of Medicine

Abstract

A 50-year-old man with a 7-year history of an ulcerative rash on the lower extremities had rapidly progressive renal failure. Monoclonal IgA (λ) was detected in his serum. Kidney biopsy revealed proliferative glomerulonephritis with dominant IgA and C₃ deposition, compatible with IgA nephropathy. Immunohistochemical staining with anti-λ, chain was negative and electron microscopic examination revealed deposits in subendothelial and mesangial areas. The findings on the skin biopsy were consistent with that of a pyoderma gangrenosum. The patient was treated with prednisolone pulse therapy followed by oral prednisolone. Renal function gradually and almost completely improved and proteinuria disappeared.<br>(Internal Medicine 36: 40-43, 1997)

Journal

• Internal Medicine

  Internal Medicine 36 (1), 40-43, 1997

  The Japanese Society of Internal Medicine

Keywords

• IgA nephropathy
• paraproteinemia
• cutaneous lesion

Details

• CRID: 1390001204866103040
• NII Article ID: 10008548113
• NII Book ID: AA10827774
• DOI: 10.2169/internalmedicine.36.40
• COI: 1:STN:280:ByiB3M7htVU%3D
• ISSN: 13497235
• ISSN: 09182918
• PubMed: 9058099
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/36/1/36_1_40/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997156441
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed