Hemodynamic Effects of Inhaled Nitric Oxide Using Pulse Delivery and Continuous Delivery Systems in Pulmonary Hypertension

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<i>Objective</i> Inhaled nitric oxide (NO) has been used for pulmonary vasodilation therapy in patients with pulmonary hypertension. Inhaled NO for awake and ambulatory patients, however, is unusual because it requires intubation or a tightly fitting facemask, and a large-scale delivery system for the safe management of toxic nitrogen oxides. We undertook this study to investigate the possibility of using inhaled NO therapy for awake and ambulatory patients with pulmonary hypertension.<br> <i>Methods</i> Patients with pulmonary hypertension underwent cardiac catheterization and hemodynamic variables were measured at the baseline, after inhaled NO using our pulse delivery system, which involved a nasal cannula and a pulse device, and after inhaled NO using a continuous delivery system.<br> <i>Patients</i> or materials We studied seventeen patients with precapillary pulmonary hypertension (4 men and 13 women; age, 41±3, ranging from 19 to 61).<br> <i>Results</i> Cardiac output was increased significantly by each system. Pulmonary vascular resistance was decreased significantly by each system. There was no significant change in mean pulmonary artery pressure, mean systemic artery pressure, or systemic vascular resistance. The concentrations of NO and nitrogen dioxide (NO<sub>2</sub>) in the expiratory gas using the pulse delivery system were 0.0 ppm as long as the pulse device was synchronized with the patient's respiratory cycle.<br> <i>Conclusion</i> Inhaled NO using our pulse delivery system changed the hemodynamic variables similarly to those when using the continuous delivery system. The concentrations of NO and NO<sub>2</sub> in the expiratory gas using the pulse delivery system were within safe limits.<br>(Internal Medicine 41: 429-434, 2002)

収録刊行物

  • Internal medicine

    Internal medicine 41(6), 429-434, 2002-06-01

    The Japanese Society of Internal Medicine

参考文献:  35件中 1-35件 を表示

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各種コード

  • NII論文ID(NAID)
    10008548362
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    6183630
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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