Detection and Monitoring of Methotrexate-associated Lung Injury Using Serum Markers KL-6 and SP-D in Rheumatoid Arthritis.

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  • MIYATA Masayuki
    Department of Internal Medicine, Fukushima Red Cross Hospital, Fukushima
  • SAKUMA Fumitaka
    Department of Internal Medicine, Fukushima Red Cross Hospital, Fukushima
  • FUKAYA Etsuko
    Department of Internal Medicine II, Fukushima Medical University School of Medicine
  • KOBAYASHI Hiroko
    Department of Internal Medicine II, Fukushima Medical University School of Medicine
  • RAI Takeshi
    Department of Internal Medicine II, Fukushima Medical University School of Medicine
  • SAITO Hironobu
    Department of Internal Medicine II, Fukushima Medical University School of Medicine
  • KASUKAWA Reiji
    Ohta General Hospital Foundation Institution for Rheumatic Diseases
  • SUZUKI Shuzo
    Department of Internal Medicine II, Fukushima Medical University School of Medicine

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Abstract

The applicability of monitoring concentrations of serum KL-6 and serum surfactant protein-D (SP-D) in the detection of methotrexate-associated lung injury (MTX pneumonitis) in patients with rheumatoid arthritis (RA) was investigated. The concentrations of these markers, sequentially measured in two patients with RA complicated with MTX pneumonitis, were increased in accordance with the severity of MTX pneumonitis. Conversely, the concentrations of these markers were decreased with the improvement of MTX pneumonitis, suggesting that the monitoring of these markers could be applicable not only for detecting the onset of MTX pneumonitis, but also for detecting the therapeutic response of MTX pneumonitis.<br>(Internal Medicine 41: 467-473, 2002)

Journal

  • Internal Medicine

    Internal Medicine 41 (6), 467-473, 2002

    The Japanese Society of Internal Medicine

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