An Analytic Study of Central Benzodiazepine Receptor in the Surgically Resected Tissues of Patients with Intractable Localization-related Epilepsy

DOI Web Site 2 Citations 16 References

Bibliographic Information

Other Title
  • 難治部分てんかん脳における中枢性ベンゾジアゼピン受容体の定量的解析
  • <SUP>125</SUP>I-iomazenil autoradiography法による手術摘出標本の検索
  • Quantitative Analysis using <SUP>125</SUP>I-iomazenil Autoradiography

Search this article

Abstract

The authors report a quantitative autoradiographic analysis of benzodiazepine receptors using the partial inverse agonist 125I-iomazenil in surgically resected tissues of 27 patients with intractable partial epilepsies. Pathological diagnosis of these tissues was; 14 mesial temporal sclerosis (MTS), 8 dysembryoplastic neuroepithelial tumor (DNT), 4 cortical dysplasia (CD) and 1 angioma. In MTS patients, the density of benzodiazepine receptors decreased in CAl, CA3 and CA4. The layers of gyrus dentatus were displaced with a thick and high density band. These findings were similar to simultaneous GABA-A stain findings. The decrease of receptor in each hippocampal structure highly correlated to the degree of cell loss in CAl, CA3 and CA4. The receptors were almost absent in the main lesions of DNT and angioma, and showed irregular distributions in the cortex around these lesions. The receptor den-sities of CD were parallel to Palmini's pathological grading. Nine cases were analyzed using 123I-iomazenil SPECT before surgery after obtaining informed consent. Eight of them revealed marked low accumulations in the areas corresponding to the epile-ptogenic foci. We conclude that our results support histochemically the clinical availa-bility of 123I-iomazenil SPECT as a non-invasive technique for detecting the changes in benzodiazepine receptor densities in patients with partial epilepsies.

Journal

Citations (2)*help

See more

References(16)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top