マウスの免疫系に及ぼす食用油脂と油脂過酸化物の影響

DOI Web Site 被引用文献2件 参考文献18件

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タイトル別名
  • Effects of Dietary Oils and Their Oxidized Products on Lymphoid Tissues and Immunocompetent Cells in Mice. Young Investigator Award of the 2001's JSNFS.
  • マウス ノ メンエキケイ ニ オヨボス ショクヨウ ユシ ト ユシ カサンカブツ ノ エイキョウ
  • Young Investigator Award of the 2001's JSNFS
  • 平成13年度日本栄養・食糧学会奨励賞受賞

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Degenerative effects on lymphoid tissues such as the thymus and Peyer's patches were observed in mice after oral administration of methyl linoleate hydroperoxide, a model of primary autoxidation products of oils, or low-molecular-weight compounds: one type of secondary autoxidation product. Immunocompetent cells such as thymus and spleen cells were modulated by feeding the mice with partially oxidized soybean oil (peroxide value, 150meq/kg) for 3 months. To evaluate the effect of in vivo lipid peroxidation on immunocompetent cells, mice were fed for 30 days on seven different dietary oils including fish oil rich in n-3 polyunsaturated fatty acids. The fish oil diet induced modulation of spleen cells and a significant increase of membranous lipid hydroperoxide (hydroperoxides of phosphatidylcholine and phosphatidylethanolamine) accumulation as a marker of oxidative senescence in red blood cells. These results suggest that dietary oxidized oils (exogenous lipid peroxides) and endogenous lipid peroxides formed in the body of animals can affect immunocompetent cells and also immune responses.

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