Effect of Euglena (Euglena gracilis Z) Enriched with Docosahexaenoic Acid on Lipid Metabolism in Stroke-Prone Spontaneously Hypertensive Rats.
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- MURAKAMI Tetsuo
- Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University
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- OGAWA Hiroshi
- Department of Hygiene, Kinki University School of Medicine
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- HAYASHI Masahiro
- Tsukuba Research Laboratory. Harima Chemicals, Inc.
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- YOSHIZUMI Hajime
- Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University
Bibliographic Information
- Other Title
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- 脳卒中易発症性高血圧自然発症ラットの脂質代謝に及ぼすDHA強化ユーグレナ(Euglena gracilis Z)の影響
- ノウソッチュウ イハッショウセイ コウケツアツ シゼン ハッショウ ラット ノ
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Abstract
Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a docosahexaenoic acid (DHA) -Euglena diet which was prepared from dry cells of Euglena gracilis Z enriched with DHA as a major protein source from 8 weeks until 20 weeks of age. The effects of the DHA-Euglena diet on lipid metabolism in the serum and liver were then investigated and the results obtained were as follows: 1) The DHA-Euglena diet had no effect on growth. Moreover, no marked change in blood pressure was observed. 2) Serum concentrations of total cholesterol and phospholipid were significantly lower than those in the control group. In addition, the serum levels of apolipoproteins A-I, A-IV, B and E were also significantly lower than those in the control group. These results suggested a hypolipidemic effect of the DHA-Euglena diet. 3) The hypolipidemic effect of the DHA-Euglena diet was due to decreases in very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), judging from the distributions of lipid and apolipoproteins among the various lipoprotein fractions. 4) The relative weight of the liver to total body weight was significantly elevated and the hepatic content of phospholipid was significantly decreased compared with the control group. However, there was no significant change in the activities of microsomal cholesterol 7α-hydroxylase and acyl-CoA: cholesterol acyltransferase.
Journal
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- Nippon Eiyo Shokuryo Gakkaishi
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Nippon Eiyo Shokuryo Gakkaishi 48 (4), 319-324, 1995
Japan Society of Nutrition and Food Science
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Details 詳細情報について
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- CRID
- 1390282681270597632
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- NII Article ID
- 10008562856
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- NII Book ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL BIB ID
- 3632004
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed