タンパク質代謝の栄養制御 Nutritional Regulation of Protein Metabolism

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著者

    • 名取 靖郎 NATORI Yasuo
    • 徳島大学医学部栄養化学教室 Department of Nutritional Chemistry, School of Medicine, The University of Tokushima

抄録

Regulatory mechanisms of hepatic protein metabolism and gene expression mediated by amino acids and vitamin B<SUB>6</SUB> were investigated. 1) Rats were nourished by total parenteral nutrition, and the effects of variations in the amino acid supply on the rates of hepatic protein synthesis and degradation were investigated. Amino acids decreased the rate of degradation whilst the rate of synthesis was relatively unaffected. Protein degradation, therefore, predominates the regulation of liver protein mass. 2) Studies on cystathionase and aspartate aminotransferase (AspAT) in the liver of vitamin B<SUB>6</SUB>-deficient rats showed that their rates of synthesis and degradation were both increased. The enhanced degradation was caused by different susceptibilities of apo- and holo-enzymes to lysosomal proteolysis. 3) Pyridoxal phosphate (PLP) was found to modulate AspAT gene expression by preventing the glucocorticoid receptor from binding to glucocorticoid-responsive elements. PLP also modulated albumin gene expression by inactivat ng the DNA-binding activity of tissue-specific transcriptional factors such as HNF-1 and C/EBP. 4) Amino acid vinfusion increased the albumin mRNA level and decreased the PLP concentration. The decrease in PLP concentration would prevent the inactivation of tissue-specific transcription factors and enhance albumin gene expression. The present study sheds new light on the physiological role of PLP as a mediator of gene regulation in protein/amino acid nutrition.

収録刊行物

  • 日本栄養・食糧学会誌 : Nippon eiyo shokuryo gakkaishi = Journal of Japanese Society of Nutrition and Food Science

    日本栄養・食糧学会誌 : Nippon eiyo shokuryo gakkaishi = Journal of Japanese Society of Nutrition and Food Science 48(6), 429-439, 1995-12-10

    Japan Society of Nutrition and Food Science

参考文献:  22件中 1-22件 を表示

  • <no title>

    MORGAN E. H.

    J. Biol. Chem. 245, 3500, 1971

    被引用文献1件

  • <no title>

    WANNEMACHER R. W.

    Biochem. J. 124, 385, 1971

    被引用文献1件

  • <no title>

    HAIDER M.

    J. Nutr. 99, 433, 1969

    被引用文献1件

  • <no title>

    SIDRANSKY H.

    J. Nutr. 101, 1153, 1972

    被引用文献1件

  • <no title>

    GARLICK P. J.

    Biochim. Biophys. Acta 414, 71, 1975

    被引用文献1件

  • <no title>

    名取靖郎

    生化学実験講座 ; タンパク質の生合成 (下) 7, 611, 1975

    被引用文献1件

  • <no title>

    GARLICK P. J.

    Biochem.J. 192, 719, 1980

    被引用文献3件

  • <no title>

    CHIKU K.

    J. Nutr. 123, 1771, 1993

    被引用文献1件

  • <no title>

    NATORI Y.

    Mechanisms and Regulation 445, 1989

    被引用文献1件

  • <no title>

    YAMADA H.

    J. Biochem. 95, 1155, 1984

    被引用文献1件

  • <no title>

    OKADA M.

    Nutrition (Life Sci. Adv.) 12, 47, 1993

    被引用文献1件

  • <no title>

    KONDO T.

    J. Biochem. 92, 1087, 1982

    被引用文献1件

  • <no title>

    SHIBUYA M.

    J. Biochem. 99, 939, 1986

    被引用文献1件

  • <no title>

    SATO A.

    J. Nutr. Sci. Vitaminol. 37, 419, 1991

    被引用文献1件

  • <no title>

    OKA T.

    Experientia 50, 127, 1994

    被引用文献1件

  • <no title>

    OKA T.

    J. Nutr. Sci. Vitaminol. 41, 363, 1995

    被引用文献1件

  • <no title>

    KONDO T.

    J. Nutr. Sci. Vitaminol. 31, 509, 1985

    被引用文献1件

  • <no title>

    OKA T.

    FEBS Lett. 331, 162, 1993

    被引用文献1件

  • <no title>

    OKA T.

    Biochem. J. 309, 243, 1995

    被引用文献1件

  • <no title>

    CEREGHINI S.

    Cell 50, 627, 1987

    被引用文献1件

  • <no title>

    MARIE P.

    Science 244, 343, 1989

    被引用文献1件

  • <no title>

    PAVE-PREUX M.

    J. Biol. Chem. 265, 4444, 1990

    被引用文献1件

各種コード

  • NII論文ID(NAID)
    10008563172
  • NII書誌ID(NCID)
    AN00311992
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    02873516
  • NDL 記事登録ID
    3919290
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-53
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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