Geriatric Changes of Extracellular Matrices of the Vocal Fold Mucosa

  • Umeno Hirohito
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Sato Kiminori
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Shirouzu Hidetaka
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
  • Nakashima Tadashi
    Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine

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Other Title
  • 声帯粘膜の細胞外マトリックスの加齢的変化

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Abstract

Viscoelastic properties of the lamina propria of human adult vocal fold mucosa are essential for vibrating behavior. These viscoelastic properties depend upon the three-dimensional structure of the extracellular matrices.<BR>The complex of extracellular matrices is very important for the viscoelastic properties of the human adult vocal fold mucosa. Geriatric changes of each extracellular matrix and its threedimentional structure of the human adult vocal fold mucosa changed the structure and viscoelasticity of the human vocal fold mucosa as a vibrating tissue, and thus is one of the causes of geriatric changes of voice. Macula flavae of human vocal folds are involved in the metabolism of extracellular matrices and their geriatric changes.

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