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- Sumitomo Shinichiro
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Kunikata-Sumitomo Mayuko
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Hashimoto Junji
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Namba Miyako
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Shrestha Prashanta
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Kurenuma Shuji
- Department of Dentistry, Kyoto Mitsubishi Hospital
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- Jayasinghe Neeta
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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- Mori Masahiko
- Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
この論文をさがす
抄録
Cellular proliferation activity in duct-ligated submandibular glands (SMGs) of rats were evaluated by using index of proliferating cell nuclear antigen (PCNA) immunostaining and 3H-thymidine incorporation. The normal SMGs showed a very low index (<0.1%) of PCNA immunostaining and 3H-thymidine incorporation in the acinar and all the ductal segments. On day 2 and 3 of duct ligation, index of PCNA staining and 3H-thymidine incorporation increased and reached a peak in degranulated granular convoluted tubules (GCTs), duct like structures (DLSs) and dilated excretory ducts (EDs). On day 5 to 10, the glands showed fibrous proliferation around the DLS, and cells in DLSs and dilated EDs had decreasing index of PCNA staining and 3H-thymidine incorporation. On day 14 and 21, the PCNA staining and 3H-thymidine incorporation had decreased and was mainly confined to the DLSs and basal cells of keratinizing epithelial masses. In the unligated SMG of the opposite side of the duct-ligated animals, proliferating cells were found mainly in the acinar compartment from the 2nd to 5th day of ligation.<br>These results suggested that in case of acceleration of secretry function of SMG, secretory cells may proliferate as for the functional adaptation. However, in the case of obstructive lesions of SMG, GCT cells and ductal basal cells may have more potential for proliferation and these cells may be the major participant cells during glandular regeneration and possibly in the histogenesis of the majority of salivary gland tumors, if not all.
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 28 (1), 1-9, 1995
日本組織細胞化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204861521792
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- NII論文ID
- 10008603317
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- NII書誌ID
- AA00508022
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- DOI
- 10.1267/ahc.28.1
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可