Expression of MUC2 Gene Product in Mucinous Carcinoma of the Breast: Comparison with Invasive Ductal Carcinoma

この論文にアクセスする

この論文をさがす

著者

抄録

We have previously reported that MUC2 gene product was dominantly expressed in the non-invasive carcinomas of the pancreas and liver (Cancer 71: 2191-2199, 1993; Int J Cancer 55: 82-91, 1993). Mucinous carcinoma (MC) of the breast usually shows less frequent lymph node metastasis and a more favorable outcome compared with invasive ductal carcinoma (IDC). In the present study, we examined the expression of MUC1 gene product (DF3, 139H2) and MUC2 gene product (anti-MRP, CCP58) immunohistochemically in 17 cases of MC (11 pure MCs, and 6 mixed MCs comprising MC and IDC) and 57 cases of IDC. Most of the pure MCs showed MUC1 positive (DF3: 11/11, 139H2: 11/11) and MUC2 positive (antiMRP: 10/11, CCP58: 11/11) pattern. Most of the mixed MCs showed MUC1 positive (DF3: 6/6, 139H2: 6/6) and MUC2 positive (anti-MRP: 5/6, CCP58: 6/6) pattern in the MC areas, but MUC1 positive (DF3: 6/6, 139H2: 6/6) and MUC2 negative (anti-MRP: 0/6, CCP58: 0/6) pattern in the IDC areas. In contrast, most of the IDCs showed MUC1 positive (DF3: 54/57, 139H2: 53/57) and MUC2 negative (anti-MRP: 0/57, CCP58: 0/57) pattern, but never showed MUC1 positive and MUC2 positive pattern. Thus, the expression of MUC2 gene product is associated with the less aggressive biological properties of MC than IDC through the production of abundant extracellular mucin forming the characteristic configuration, since MUC2 glycoprotein is a secretory mucin, while MUC1 glycoprotein is membrane-associated.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(3), 239-246, 1995-06-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  35件中 1-35件 を表示

被引用文献:  8件中 1-8件 を表示

各種コード

  • NII論文ID(NAID)
    10008603798
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ