Selective Transport of Glycolipid Molecules Containing N-acetylgalactosamine to the Basolateral Domain of Mouse Hepatocyte Plasma Menbrane

この論文にアクセスする

この論文をさがす

著者

抄録

To determine whether N-acetylgalactosamine (GaINAc)-or galactose (Gal)-containing components are present on the plasma membrane of hepatocytes, and, if so, to examine the distribution of the components on the plasma membrane, the binding of <i>Dorichos biflorus</i> agglutinin or soybean agglutinin to the plasma membrane of mouse hepatocytes was demonstrated histochemically. In addition, to determine the nature of the components containing GaINAc or Gal, the lectin binding sites were extracted from the plasma membrane and subjected to electrophoresis followed by lectin binding assay. Plasma membrane fractions from mouse hepatocytes included GaINAc-or Gal-containing components, and the components were glycolipid. The terminal sugar in the sugar chain of the glycolipid molecules was GaINAc. The glycolipid molecules containing GaINAc were predominantly localized along the basolateral (sinusoidal plus lateral) domain of the plasma membrane. Colchicine inhibited the transport of the glycolipid molecules to the plasma membrane. Therefore, glycolipid molecules containing GaINAc are selectively transported to the basolateral domain of the plasma membrane of mouse hepatocytes via vesicular transport.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(4), 357-364, 1995-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  32件中 1-32件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008604254
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ