Detection of Vascular Dendritic Cells and Extracellular Calcium-Binding Protein S-100 in Foci of Calcification in Human Arteries

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著者

    • BOBRYSHEV Yuri V.
    • Surgical Professiorial Unit, St. Vincents' Hospital, University of New South Wales

抄録

A new explanation of why calcification develops in arterial vessels is proposed. Some of recently described CD1a<sup>+</sup>/S-100<sup>+</sup> <i>vascular dendritic cells</i> have been found to undergo destruction in athero-prone areas of the aorta and in atherosclerotic lesions (Bobryshev and Lord, <i>Arch. Histol. Cytol</i>., 1995). Lysis of these <i>vascular dendritic cells</i> should release their cellular components into the extracellular space, including S-100 which belongs to the family of calcium-binding proteins. In the present study we examined the possible association of <i>vascular dendritic cells</i> with calcification in atherosclerosis and found that <i>vascular dendritic cells</i> were present in early foci of calcification in the arterial intima and in atherosclerotic lesions. This finding suggests the possible involvement of <i>vascular dendritic cells</i> in the process of arterial wall calcification. <i>Vascular dendritic cells</i> and calcifying vascular cells may be related where a subset of <i>vascular dendritic cells</i> represents calcifying vascular cells in the arterial wall. Extracellularly distributed S-100 protein was also found in association with early calcified deposits. The detection of calcium-binding S-100 protein in the extracellular matrix suggests that molecular mechanisms are involved in atherosclerotic calcification, which is quite different from the previously postulated mechanisms involving bone-associated proteins.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(4), 371-380, 1995-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604311
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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