Fiber Type Profile Change after Partial and Total Denervation in Rat Soleus Muscles

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The short-term effects after experimental partial and total denervation on histochemical fiber type profiles were studied in rat soleus muscles by the myofibrillar ATPase stain. In 58 control soleus muscles, a total of 155788 fibers were counted, comprising type 1 (75.1%), type 2A (13.3%), type 2B (1.4%) and type 2C (10.3%), respectively. In 34 animals with total denervation, including 17 with soleus nerve resection at 1cm before entering the soleus muscle and 17 with total sciatic neurectomy, the proportion of type 1 fiber was decreased in denervated muscles to 39.1% 5 weeks after the procedures. In parallel with a decrease in type 1 fiber proportion, undifferentiated type 2C fibers increased, thereby suggesting muscle fiber type dedifferentiation taking place in totally denervated muscle. In contrast, 24 muscles with partial denervation showed a decreased proportion of type 1 fibers at the initial stage followed by an increase in type 1 fiber to 89.0% 5 weeks after denervation, resulting from an active reinnervating process.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(5), 431-437, 1995-10-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604515
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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