Atrial Specific Granules : An Intracellular Calcium Store

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著者

    • LING Yiping
    • Department of Biophysics, Shanghai Medical University
    • YU Zhang
    • Department of Biophysics, Shanghai Medical University
    • YU Wenquian
    • Department of Biophysics, Shanghai Medical University
    • OGAWA Kazuo
    • Department of Anatomy, Faculty of Medicine, Kyoto University

抄録

This work presents evidence that the atrial specific granule (ASG) is one of the intracellular calcium stores (ICaSs). First, a high calcium (Ca) concentration up to 81 mmol/kg dry wt. in ASG was determined by using an electron microscopic x-ray microanalysis technique. Second, Ca<SUP>2+</SUP>-ATPase was observed on the membranes of ASG and of the sarcoplasmic reticulum (SR) by using the cytochemical technique. Third, the activities of the Ca<SUP>2+</SUP>-ATPase on both the ASG membrane and on the SR memebrane were inhibited by 0.1 mM quercetin, but not by 0.1mM oligomycin. Because SR is an established ICaS, the similarities found in the present work between ASG and SR led us to postulate that ASG may be an ICaS in atrial cardiocytes, and that the Ca<SUP>2+</SUP>-ATPase on ASG membrane may pump Ca<SUP>2+</SUP> from cytosol into ASG and thus play a role in maintaining the high Ca concentration in it.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(6), 507-511, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604669
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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