Age-Related Changes of the Argyrophilic Nucleolar Organizer Regions in Mouse Neocortical Neurons

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著者

    • FUSHIKI Shinji
    • Department of Dynamic Pathology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine
    • KINOSHITA Chikako
    • Department of Dynamic Pathology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine
    • TSUTSUMI Yoko
    • Department of Dynamic Pathology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine
    • NISHIZAWA Yoshio
    • Department of Dynamic Pathology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine

抄録

To evaluate the developmental changes of the nucleolar activity of neurons, we enumerated the number of argyrophilic nucleolar organizer regions (AgNOR) in neocortical neurons of embryonic and postnatal mouse brains. The number of AgNOR changed with time, peaking at late embryonic life and falling gradually through 12 weeks postnatally. Our observation gives indirect evidence that the number of AgNORs is a marker of ribosomal RNA transcriptional activity as well as of ribosomal protein synthesis activity in neurons but not of their proliferative activity, because they are post-mitotic. These findings indicate that the AgNOR staining technique could be a useful adjunct in assessing neuronal activity of the brain.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(6), 533-538, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604763
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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