Regeneration of Paneth Cells after Dithizone Treatment

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著者

    • MIYAKE Naoki
    • Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine
    • SAWADA Mitsutaka
    • Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine
    • HIAI Hiroshi
    • Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine

抄録

Injection of dithizone, a zinc chelating agent, induced selective killing of intestinal Paneth cells within a few min by forming toxic insoluble zinc-dithizonate complexes. However, regeneration of Paneth cells took place right after dithizone treatment and resumed the normal level as early as 72 hr with over-shooting persistent for 2 weeks. The process or regeneration in intestinal crypts was studied by means of morphology, uptake of the thymidine analog 5-bromo-2′-deoxy-uridine and immunohistochemical staining of Paneth cell differentiation markers such as lysozyme and zinc-binding proteins. It was found that Paneth cells regenerated without cell division and DNA synthesis apparently by direct transformation of non-Paneth crypt base columnar cells. Dithizone induced a transient wave of cell growth in all compartments of the intestinal crypt.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(6), 549-553, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604818
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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